One mouse at a time: new approach to testing potential drugs for children’s cancers. Drugs can be tested against many more genetic variants of the same cancer

A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In new research to be presented at … Continue reading

Published Thursday, October 22nd, 2020 at 12:01 am
Posted in Cancer

Researchers identify genetic variants linked to toxic side effects from bevacizumab

In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The … Continue reading

Published Thursday, October 22nd, 2020 at 12:01 am
Posted in Cancer, Cardiology

Existing heart drugs may help cancer patients respond better to PD(L)1 immunotherapy

Researchers have found that a class of commonly-used heart drugs may also improve patients’ responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics, … Continue reading

Published Thursday, October 22nd, 2020 at 12:01 am
Posted in Cancer, Cardiology

Young women who suffer a heart attack have worse outcomes than men

Women aged 50 or younger who suffer a heart attack are more likely than men to die over the following 11 years, according to a new study published in the European Heart Journal [1]. The study found that, compared to … Continue reading

Published Wednesday, October 14th, 2020 at 12:05 am
Posted in Cardiology

Drug combination proves effective in rare peripheral nerve sheath tumours: research in cancer cells and mice has ‘immediate translational implications’

Malignant tumours of the peripheral nerve are rare but aggressive and very difficult to treat successfully. Now, researchers in the US have shown that a combination of two types of anti-cancer drugs, MEK and SHP2 inhibitors, is effective in targeting … Continue reading

Published Friday, October 9th, 2020 at 12:01 am
Posted in Cancer

Catheter ablation linked to reduced risk of dementia in patients with atrial fibrillation

People with atrial fibrillation have a reduced risk of dementia if they undergo a procedure called catheter ablation to restore the normal rhythm of their heart, according to a new study published in the European Heart Journal [1]. Previous work, … Continue reading

Published Wednesday, October 7th, 2020 at 12:05 am
Posted in Cardiology

Treating abnormal breast tissue with surgery and radiotherapy reduces cancer risk but the benefits diminish with time

A major study of women with ductal carcinoma in situ (DCIS) – a breast condition that can become invasive cancer – has shown that surgery to remove the tissue followed by radiotherapy offers better protection compared to surgery alone. The … Continue reading

Published Saturday, October 3rd, 2020 at 4:00 pm
Posted in Cancer

The mode of detection of high-risk breast cancers is linked to patient prognosis

Breast cancers that are detected in the interval between national screening programme mammograms have a worse prognosis than those detected at the time of a screening, even if they have the same biology, according to research presented at the 12th … Continue reading

Published Saturday, October 3rd, 2020 at 12:01 am
Posted in Cancer

Increased risk of cardiovascular disease in women treated for breast cancer can be predicted with computer analysis of routine scans

Automated analysis of breast cancer patients’ routine scans can predict which women have a greater than one in four risk of going on to develop cardiovascular disease, according to research presented at the 12th European Breast Cancer Conference. Women who … Continue reading

Published Friday, October 2nd, 2020 at 12:01 am
Posted in Cancer, Cardiology

HER2 positive breast cancer patients live longer if drugs given before surgery eradicate tumour: final results of nine-year survival outcomes from NeoALTTO BIG-06 trial

Final analysis of results from a randomised clinical trial of lapatinib and trastuzumab given before surgery in patients with early HER2-positive breast cancer has found that women who had no signs of residual disease after treatment (known as a pathological … Continue reading

Published Friday, October 2nd, 2020 at 12:01 am
Posted in Cancer